血清Cys C、HCY和hs-CRP检测在糖尿病肾病中的诊断价值

祁艾红; 韩卫全

血清Cys C、HCY和hs-CRP检测在糖尿病肾病中的诊断价值

祁艾红^,,
韩卫全

- 武汉市第五医院检验科(武汉, 430050)

详细信息

通讯作者: 祁艾红,E-mail:qiaihong@163.com

中图分类号: R587.1

收稿日期: 2013-06-06

Diagnostic value of serum cystatin C, homocysteine and high sensitivity C-reactive protein in diabetic nephropathy

QI Aihong^,,
HAN Weiquan

- Wuhan Fifth Hospital Laboratory, Wuhan, 430050, China

More Information

Corresponding author: QI Aihong, E-mail: qiaihong@163.com

Received Date: 06 June 2013

摘要

摘要: 目的：探讨血清胱抑素C（Cys C）、同型半胱氨酸（HCY）、超敏C反应蛋白（hs-CRP）联合检测在糖尿病（DM）患者肾损害中的诊断价值。方法：研究175例DM患者和40例健康对照者的血清Cys C、HCY、hs-CRP水平变化。血清Cys C和hs-CRP采用乳胶颗粒增强免疫比浊法，血清HCY采用循环酶法测定。结果：DM患者正常白蛋白尿组的血清Cys C、HCY、hs-CRP水平较对照组明显升高（P<0.05），DM患者微量白蛋白尿组和临床蛋白尿组较对照组血清Cys C、HCY水平升高显著（P<0.01），血清Cys C、HCY、hs-CRP水平随糖尿病肾病（DN）的发生以及严重程度逐渐增高。结论：血清Cys C、HCY和hs-CRP检测可作为早期诊断DN较敏感的指标；对监测早期DN的发生和病情发展程度有重要意义。
- 胱抑素C /
- 同型半胱氨酸 /
- C反应蛋白 /
- 糖尿病肾病
Abstract: Objective: To study the diagnostic value of the combined detection of serum cystatin C (Cys C),homocysteine (HCY) and high sensitivity C-reactive protein (hs-CRP)in diabetic nephropathy.Method: The changes of serum Cys C,HCY and hs-CRP in 175 cases of DM patients and 40 healthy control group were compared.The serum Cys C and hs-CRP were conducted by using latex particle enhanced immunoturbidimetric assay,the serum HCY was conducted by using cycle enzymatic assay.Meanwhile,the rates of combined detection were analyzed.Result: DM patients with normal albuminuria group,serum Cys C,HCY and hs-CRP level were significantly higher than those of normal control group (P<0.05),serum Cys C and HCY levels were higher significantly (P<0.01) in DM patients with microalbuminuria and clinical proteinuria than normal control group,the level of serum Cys C,HCY and hs-CRP gradually increased with the occurrence and severity of diabetic nephropathy.Conclusion: The detection of serum Cys C,HCY and hs-CRP could be used as a sensitive indicator for early diagnosis of DN and monitoring the occurrence of early DN and the degree of progression of the disease.
- cystatin C /
- homocysteine /
- high sensitivity C-reactive protein /
- diabetic nephropathy

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参考文献(12)

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