Detection of maycoplasma in female genital ducts and analysis of antibiotic resistance
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摘要: 目的：对妇科患者生殖道内支原体感染情况及耐药性进行分析。方法：选取580例妇科门诊患者，用一体化试剂盒进行人型支原体（Mh）和解脲脲原体（Uu）培养和检测。结果：580例妇科门诊患者中支原体培养结果阳性有315例，检出率为54.3%（315/580），其中Mh和Uu的检出率分别为4.7%（15/315）和61.0%（192/315），Mh和Uu的混合感染率为34.3%（108/315），Uu的检出率和Mh之间的差异有统计学意义，前者明显高于后者（P<0.05）。对于单纯的Uu感染，环丙沙星和氧氟沙星耐药性最高，均超过75%，其他10种药物耐药性均小于50%；单纯Mh感染对美满霉素、强力霉素和交沙霉素均有较高的敏感性，但对于罗红霉素、克拉霉素、阿奇霉素、红霉素、环丙沙星和氧氟沙星均有较高耐药性，超过70%。Mh和Uu的混合感染对于环丙沙星、氧氟沙星、红霉素、罗红霉素、阿奇霉素和克拉霉素均有较高的耐药性，超过70%。结论：女性生殖道内支原体检出率较高，且以单纯Uu感染为主；治疗方面，强力霉素、交沙霉素和美满霉素具有很高的敏感性，可以作为一线药物进行使用。Abstract: Objective: To investigate the mycoplasma infection in female genital ducts and its drug resistance.Method: The Mycoplasma culture and the drug resistance test were done in cervical specimens from 580 cases of female genital infection patients in gynaecological.Result: The mycoplasma culture detection rate was 54.3%(315/580),among which Mh was for 4.7%(15/315),Uuaccounted for 61.0%(192/315)and both Uu and Mh for 34.3%(108/315).For the only Uu,Ciprofloxacin and ofloxacin had the highest drug resistance which were both above 70%,the others were all lower than 50%.For the only Mh,minocycline,doxycycline and josamycin all had higher sensitivity,the others all had higher drug resistances which were all more than 70%.Conclusion: Mycoplasma infection in the female genital tract commonly caused by Uu.Mycoplasma test and drug sensitivity should be done in clinic as many species of Mycoplasma resist to routine antibiotics,and reasonable usage of antibiotics should be necessary.
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Key words:
- mycoplasma /
- female genital duct /
- resistance analysis
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