Diagnosis value of plasma galanin in type 2 diabetic retinopathy patients
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摘要: 目的:探讨血浆甘丙肽水平与2型糖尿病性视网膜病变的相关性及诊断价值。方法:245例2型糖尿病患者按照眼底检查结果分为2型糖尿病无视网膜病变组(NDR组)95例,2型糖尿病非增殖性视网膜病变组(NPDR组)78例和2型糖尿病增殖性视网膜病变组(PDR组)72例,另选择65例同期体检中心体检的健康人群作为对照组,统计4组受试对象临床资料,常规检查血糖、血脂等临床指标,酶联免疫吸附测定法检测血浆甘丙肽水平。Logistic回归分析影响NPDR和PDR的危险因素,利用受试者工作曲线(ROC)预测甘丙肽对NPDR或PDR的诊断价值。结果:与对照组比较,NDR组、NPDR组、PDR组收缩压(SBP)、舒张压(FBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(Hs-CRP)、胰岛素抵抗指数(HOMA-IR)、血浆甘丙肽明显升高,高密度脂蛋白胆固醇(HDL-C)明显降低,差异有统计学意义(P＜0.05)。与NDR组比较,NPDR组、PDR组糖尿病病程、SBP、HOMA-IR、Hs-CRP、血浆甘丙肽明显升高,差异有统计学意义(P＜0.05)。与NPDR组比较,PDR组糖尿病病程、Hs-CRP、血浆甘丙肽明显升高,差异有统计学意义(P＜0.05)。NPDR和PDR患者血浆甘丙肽与糖尿病病程、FBG、HbA1c、TC、HOMA-IR和Hs-CRP呈正相关(均P＜0.05)。Logistic回归分析显示,HbA1c、HOMA-IR、Hs-CRP、甘丙肽水平是影响NPDR的独立危险因素;糖尿病病程、HbA1c、HOMA-IR、Hs-CRP、甘丙肽水平是影响PDR的独立危险因素(均P＜0.05)。甘丙肽诊断NPDR的最佳临界值为21.94 ng/L,敏感度为72.0%,特异度为91.6%,ROC曲线下面积(AUC)为0.894(95%CI: 0.838~0.936, P＜0.05)。甘丙肽诊断PDR的最佳临界值为24.92 ng/L,敏感度为69.4%,特异度为86.1%,AUC为0.835(95%CI: 0.764~0.892, P＜0.05)。结论:血浆甘丙肽是影响NPDR和PDR的独立危险因素,通过检测血浆甘丙肽水平能够为诊断NPDR和PDR提供参考。Abstract: Objective:To explore the correlation between plasma galanin levels and type 2 diabetic retinopathy and its diagnostic value. Method:A total of 245 cases of type 2 diabetic patients were divided into no diabetes mellitus retinopathy group (NDR) 95 cases, nonproliferative DR group (NPDR) 78 cases and proliferative DR group (PDR) 72 cases according to the results of fundus examination, another 65 healthy persons who underwent physical examination in medical examination center at same period were selected as the control group, the clinical data of four groups were statistically analyzed. Blood glucose, blood lipids and other clinical indicators were routine examinated, plasma galanin levels were measured by enzyme linked immunosorbent assay. The risk factors of NPDR and PDR were analyzed by Logistic regression, the diagnostic value of galanin and other indicators for NPDR or PDR were used by receiver operating curve (ROC). Result:Compared with control group, the SBP, FBG, HbA1c, TG, LDL-C, HOMA-IR, Hs-CRP and galanin in NDR, NPDR and PDR group were significantly increased, HDL-C was significantly lower, and the difference was statistically significant (P<0.05). Compared with NDR group, the duration of diabetes, SBP, HOMA-IR, Hs-CRP and galanin in NPDR and PDR group were significantly increased, and the difference was statistically significant (P<0.05). Compared with NPDR group, the duration of diabetes, Hs-CRP and galanin in the PDR group was significantly increased, and the difference was statistically significant (P<0.05). The plasma level of galanin was significantly positive correlated with diabetes duration, FBG, HbA1c, TC, HOMA-IR and Hs-CRP (all P<0.05). Logistic multivariate regression analysis showed that HbA1c, HOMA-IR, Hs-CRP and galanin were risk factors for NPDR patients, and duration of diabetes, HbA1c, HOMA-IR, Hs-CRP and galanin were risk factors for PDR patients (all P<0.05). The optimal
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Key words:
- galanin /
- type 2 diabetes mellitus /
- diabetic retinopathy /
- diagnosis /
- correlation
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[1] 中华医学会眼科学会眼底病学组.我国糖尿病视网膜病变临床诊疗指南(2014年)[J].中华眼科杂志,2014,50(11):851-865.
[2] Day TE, Ravi N, Xian H, et al.Sensitivity of diabetic retinopathy associated vision loss to screening interval in an agent-based/discrete event simulation model[J]. Comput Biol Med,2014,47:7-12.
[3] Nergiz S, AltçnkayaöS, Küçük M, et al.Circulating galanin and IL-6 concentrations in gestational diabetes mellitus[J]. Gynecol Endocrinol, 2014,30:236-240.
[4] Fang P, Min W, Sun Y, et al. The potential antidepressant and antidiabetic effects of galanin system[J]. Pharmacol Biochem Behav,2014,120:82-87.
[5] Zhang Z, Gu C, Fang P, et al.Endogenous galanin as a novel biomarker to predict gestational diabetes mellitus.[J]. Peptides,2014,54:186-189.
[6] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[7] Tanaka K, Kawai T, Saisho Y,et al.Relationship between Stage of Diabetic Retinopathy and Pulse Wave Velocity in Japanese Patients with Type 2 Diabetes[J].J Diabetes Res,2013,2013:193514.
[8] 桂玉敏,郭敬.血清C肽在评估非增生型糖尿病视网膜病变预后中的作用[J].中华实验眼科杂志,2013,31(8):775-778.
[9] 程金涛,戚金泽,梁佳美,等.糖尿病视网膜病变患者血清apelin与血脂水平观察[J].中华眼底病杂志,2015,31(2):139-142.
[10] Ayhan Tuzcu E, Ar?ca S, Ilhan N, et al.Relationship between mean platelet volume and retinopathy in patients with type 2 diabetes mellitus[J]. Graefes Arch Clin Exp Ophthalmol,2014,252:237-240.
[11] 张真稳,方彭华,顾春美,等.妊娠糖尿病患者血浆甘丙肽的表达及意义[J].广东医学,2015,(3):385-386.
[12] Fang P, Yu M, Shi M, et al.The Neuropeptide Galanin Benefits Insulin Sensitivity in Subjects with Type 2 Diabetes[J]. Curr Protein Pept Sci, 2013,14:669-673.
[13] Mansouri S, Barde S, Ortsäter H, et al.GalR3 activation promotes adult neural stem cell survival in response to a diabetic milieu[J]. J Neurochem, 2013,127:209-220.
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