Two cases of diffuse alveolar hemorrhage following allogeneic hematopoietic stem cell transplantation and literature review
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Abstract: Two patients diagnosed with acute lymphoblastic leukemia occurred diffuse alveolar hemorrhage (DAH) after they accepted the sib allogeneic hematopoietic stem cell transplantation (allo-HSCT).The main clinical presentations were the progressive dyspnea,hypoxemia and hemoptysis.Radiological data confirmed the presence of DAH,and there was no clear evidence of pathogens.One of them achieved standard doses of corticosteroids treatment,the symptoms were complete relieved and lung lesions gradually absorbed.The other was progressive hypoaxemia,then developed respiratory failure and required mechanical ventilation support,though given large doses of corticosteroids and anti-CD25 monoclonal antibody therapy,the condition was improved in short time,and eventually developed to multiple organ failure and death.DAH following allo-HSCT was a non-infectious lung complication.At present,there is no definite guideline of treatment.
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