常州地区疑难输血患者不规则抗体分析

闵志军; 张建伟; 曹伟春; 徐立; 许飞

常州地区疑难输血患者不规则抗体分析

- 常州市中心血站(江苏常州, 213014)

详细信息

中图分类号: R457.1

收稿日期: 2012-11-29

Analysis of irregular RBC antibodies in 231 patients from Changzhou

- Changzhou Blood Center, Changzhou, 213014, China

Received Date: 29 November 2012

摘要

摘要: 目的：分析常州地区患者中不规则抗体检出情况。方法：对2011-05-2012-11常州地区各医院送检的疑难配血标本231例，应用盐水、抗球蛋白法、凝聚胺法检测不规则抗体。结果：共确认血型不规则抗体54例。其中自身抗体13例（高效价冷凝集素9例；未知的特异性自身IgG型抗体4例），药物引起的抗体2例，同种特异性抗体39例，分别为：抗-E 15例（1例为IgM型）、抗-M 13例、抗-E伴抗-c 1例、抗-C伴抗-e 1例、抗-D 8例（1例为IgM型）、抗-Leb 1例。结论：检出的不规则抗体与文献报道有较大差异，抗-M检出率较高，Rh系统抗体差别不大。
- 血型 /
- 不规则抗体 /
- 频率
Abstract: Objective: To estimate the frequency and specificity of clinically significant irregular RBC antibodies in hospitalized patients in Changzhou.Method: A total of 231 blood samples were collected from hospitals in Changzhou.Modified polybrene test and conventional serologic methods were used for the identification of antibody specificity.Result: Clinically significant irregular antibodies were found in 54 patients.Thirteen samples were autoantibodies(excluding cold autoantibodies 9,unconfirmed IgG antibodies 4),and 2 samples were drug antibodies,others were alloantibodies.The qualities of alloantibodies found among patients were:anti-D 8(excluding IgM 1),anti-E 15(excluding IgM 1),anti-cE 1,anti-Ce 1,anti-M 13,anti-Leb 1.Conclusion: Our data showed significant difference compared with Caucasian data.We had found more anti-M in Changzhou area,and there was no difference between Changzhou and other area in Rh system antibodies.
- blood group /
- irregular antibody /
- frequency