Abstract: Objective:To investigate the infection situation of the four communicable diseases hepatitis B,hepatitis C,syphilis and AIDS among pregnant women in this area.Method:16 348 predelivery pregnant women received the pregnancy testing,including hepatitis B virus serum markers(HBVM),anti-hepatitis C virus antibody(anti-HCV),human immunodeficiency virus antibody(anti-HIV) and syphilis antibody.Result:There were 1372(8.39%) women hepatitis B virus surface antigen(HBsAg)-positive,17(0.1%)women anti-HCV positive,333(2.04%) syphilis-positive (RPR and TPPA) and 2 anti-HIV positive in 16348 pregnant women.The infectious incidence of hepatitis B was rising year after year.There was no significant difference between 2010,2011 and 2009(P>0.05).The Infectious incidence of hepatitis C was low and dropping year by year.The infectious incidence of syphilis was rising from 1.59% in 2009 to 2.34% in 2011,there was no statistic significance between 2009 and 2010(P>0.05),and there was a significant difference between 2011 and 2009(P<0.01).Conclusion:Pregnant woman is the important factor of vertical transmission of blood-borne diseases.It’s should pay highly attention to the group of pregnant women to reduce vertical transmission of blood-borne diseases.There may be a great significance for healthy pregnant women to do antenatal examination of HIV,HBV,HCV and syphilis,and take intervening measures in time.